Classic diseases revisited Acne: a review of immunologic and microbiologic factors

Acne vulgaris is a self-limiting skin disorder seen primarily in adolescents, whose aetiology appears to be multifactorial. The four main aetiological factors are hypercornification of the pilosebaceous duct, increased sebum production, colonization with Propionibacterium acnes, and subsequently the production of inflammation. Considerable investigation has addressed the immunologic reaction to extracellular products produced by the acne-causing organism, P acnes. The immunologic response involves both humoral and cellmediated pathways. Further research should clarify the role of complement, cytotoxins, and neutrophils in this acne-forming response.